The Highest Omega-3 Dose Ever Studied (25 grams per day)

The Highest Omega-3 Dose Ever Studied (25 grams per day)

When Dr. Bill Harris began researching omega-3 in the early 1980s, he was looking for an impact on cholesterol with what would be considered a high dose by today’s standards: around 25 effective grams per day of omega-3 from salmon. However, rather than finding an effect on cholesterol, they found a nearly 80% drop in triglycerides among patients with Fredrickson Type V hypertriglyceridemia.

While this dose is, no doubt, clinically excessive, the tolerability of even high doses used in the past provides context on just how hard it is to determine a true “tolerable upper intake level” when it comes to omega-3. Listen for discussion of bleeding risk, omega-6 to omega-3 ratios, how the FDA set the recommended dose of prescription omega-3, and more.

Watch the full interview here:

00:00:00 – 25 grams per day
00:03:25 – Is there a blood thinning effect?
00:09:06 – Individuals need different amounts
00:09:58 – Clinical trials (higher doses needed)
00:13:00 – How the FDA determined 4g dose
00:13:50 – Omega-6 to omega-3 ratio

Episode originally aired December 7th, 2021.


Lillian Harvey
Lillian Harvey
Lillian is a freelance writer based in Des Moines, Iowa. Passionate about all things wellness. She aims to bring seemingly intimidating food and fitness concepts down to earth for readers.
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